Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability
نویسندگان
چکیده
منابع مشابه
Introducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications
Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubili...
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Meloxicam (MLX) has poor water solubility which leads to slow absorption following oral administration; hence, immediate release tablet is unsuitable in the treatment of acute pain. The aim of this study was to prepare a novel fast ultra-fine self-nanoemulsifying drug delivery system (UF-SNEDDS) of MLX for oral administration to facilitate drug release process in the stomach as well as comparin...
متن کاملDesign and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D
BACKGROUND The main purpose of this research was to design a self-nanoemulsifying drug delivery system (SNEDDS) for improving the bioavailability of cyclovirobuxine D as a poorly water-soluble drug. MATERIALS AND METHODS Solubility trials, emulsifying studies, and pseudo-ternary phase diagrams were used to screen the SNEDDS formulations. The optimized drug-loaded SNEDDS was prepared at a mass...
متن کاملPreparation and evaluation of a self-nanoemulsifying drug delivery system loaded with Akebia saponin D–phospholipid complex
BACKGROUND Akebia saponin D (ASD) exerts various pharmacological activities but with poor oral bioavailability. In this study, a self-nanoemulsifying drug delivery system (SNEDDS) based on the drug-phospholipid complex technique was developed to improve the oral absorption of ASD. METHODS ASD-phospholipid complex (APC) was prepared using a solvent-evaporation method and characterized by infra...
متن کاملPreparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex
BACKGROUND As a poorly water-soluble drug, the oral application of morin is limited by its low oral bioavailability. In this study, a new self-nanoemulsifying drug delivery system (SNEDDS), based on the phospholipid complex technique, was developed to improve the oral bioavailability of morin. METHODS Morin-phospholipid complex (MPC) was prepared by a solvent evaporation method and characteri...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2015
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2014.11.001